The HPV-1000 is a police motorcycle in Grand Theft Auto: San Andreas ridden by San Andreas Police Department police bikers. It is very fast and agile, although Carl can fall off easily if they have minimal "bike skill". Unless the Rhino or Hunter is available, this bike is a good choice for completing the Vigilante side mission - mainly because the player can fire a submachine gun straight ahead, allowing them to take out the opponent easily. It can usually slip round the side of vehicles, unlike patrol cars. It is a unique model that isn't shared by another motorcycle, it looks similar to a police Kawasaki KZ1000.

The HPV-1000 makes an important appearance in the mission Cop Wheels, in where protagonist Carl Johnson needs to steal four HPV-1000s in various places around Las Venturas for the heist and needs to deliver it to a moving Packer.

The name may be a reference to the human papillomavirus (HPV).